Alfentanil kinetics in renal insufficiency |
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Authors: | A. Van Peer M. Vercauteren H. Noorduin R. Woestenborghs J. Heykants |
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Affiliation: | (1) Departments of Pharmacokinetics and Clinical Research, Janssen Pharmaceutica, Beerse, Belgium;(2) Department of Anaesthesia, University of Antwerp, Antwerp, Belgium |
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Abstract: | Summary Alfentanil 100 µg/kg was administered as an i.v. bolus to 9 patients with severe chronic renal dysfunction (creatinine clearance 1.0±1.2 ml/min) requiring regular haemodialysis. Plasma alfentanil concentrations were measured by a specific radioimmunoassay. Individual plasma concentration-time curves were fitted to a two-compartment open model. Mean distribution and elimination half-lives were 3.7 min and 58 min, respectively. The apparent volumes of distribution of the central compartment and the total volume of distribution at steady-state were 91 ml/kg and 304 ml/kg, respectively. Alfentanil plasma clearance was 5.3±2.5 ml/min/kg. All the patients tolerated alfentanil well and no side-effects nor delayed recovery were observed. |
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Keywords: | alfentanil uraemia i.v. administration pharmacokinetics |
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