如何处理临床研究中研究者的经济利益冲突?--主体、原则与方法

临床研究中研究者的经济利益冲突可能会影响到受试者的安康和研究的客观性、可靠性.我们是否应该处理这种利益冲突?应该由谁处理?根据哪些伦理原则处理?具体采取哪些措施处理?围绕这些问题,本文批判地分析了反对处理利益冲突的观点,主张研究者、研究机构、行业组织、政府部门和学术期刊多方共同努力,根据公正、有利/不伤害、尊重三个伦理原则,采取公开、管理和禁止等措施,处理研究者的经济利益冲突,以保护受试者的安康和研究的客观性.

How to Deal with Investigators′Financial Conflict of Interest in Clinical Research: Subject, Principles and Strategies

Investigators' financial conflict of interest in clinical research may compromise the well-being of subjects,the objectivity of the research results.Should this kind of conflict of interest be deal with? Who should deal with it? What ethical principle should be adopted? What strategies should we use? This article will argue that investigators,institutes,professional associations,governmental agencies and medical journals should deal with financial conflict of interest together.They can use some strategies such as disclosure,management and prohibition according to the principles of Justice,Nonmaleficence/Beneficence,and Respect for Persons.