前列清颗粒的抗炎、镇痛作用

目的:评价前列清颗粒的抗炎、镇痛作用。方法:设前列清颗粒高、中、低3个剂量组以及吲哚美辛对照组和空白对照组,采用大鼠角叉菜胶足跖肿胀实验和小鼠二甲苯耳郭肿胀试验,观察前列清颗粒的抗炎作用;采用小鼠热板镇痛试验和扭体镇痛试验,观察前列清颗粒的镇痛作用。结果:与空白对照组比较,前列清颗粒3个剂量组能明显减轻大鼠足跖肿胀率(P<0.01);前列清颗粒中、高剂量组对小鼠耳郭肿胀具有显著的抑制作用(P<0.05,P<0.01);3组均能明显延长小鼠痛阈值(P<0.05,P<0.01);显著延长小鼠扭体的潜伏时间,减少扭体次数(P<0.05,P<0.01)。结论:前列清颗粒具有一定的抗炎、镇痛作用。

Effects of Qianlieqing granule on chronic bacterial prostatitis in rats

OBJECTIVE To evaluate the anti-inflammatory and analgesic effects of Qianlieqing granule(QLQG) in animal models.METHODS The rats were divided into five groups: groups of high,middle and low dose of QLQG,indometacin control group and blank control group.The anti-inflammatory effects were studied by carrageenin-induced paw edema in rats and dimethylbenzene-induced auricle swelling in mice.The analgesic effects were studied by hot-plate test and acetic acid-induced writhing experiment in mice.RESULTS The paw swelling percentage of rats in three QLQG groups was lightened significantly than that in the blank control group(P<0.01);Middle and high dose QLQG significantly inhibited auricle swelling of mice(P<0.05,P<0.01);Three dosages of QLQG prolonged the pain threshold of mice(P<0.05,P<0.01),lengthened latent time and reduced frequency of writhing in mice(P<0.05,P<0.01).CONCLUSION QLQG has certain anti-inflammatory and analgesic effects.