Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm |
| |
Authors: | Steinberg Doron Feldman Mark Ofek Itzhak Weiss Ervin I |
| |
Affiliation: | Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel. dorons@cc.huji.ac.il |
| |
Abstract: | BACKGROUND: Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria. OBJECTIVES: In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus. RESULTS: The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05). CONCLUSIONS: Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|