The effect of metabolic control on leucine metabolism in Type 1 (insulin-dependent) diabetic patients |
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Authors: | Dr A M Umpleby M A Boroujerdi P M Brown E R Carson P H Sönksen |
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Institution: | (1) Department of Medicine, St. Thomas' Hospital, UK;(2) Department of Systems Science, The City University, London, UK;(3) Department of Medicine, St Thomas' Hospital, Lambeth Palace Road, SE1 7EH London, UK |
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Abstract: | Summary Leucine production rate, metabolic clearance rate and oxidation rate were measured in 10 Type 1 (insulin-dependent) diabetic
patients after (1) 24 h insulin withdrawal, (2) conventional insulin therapy and (3) an overnight insulin infusion to maintain
normoglycaemia, and in 10 control subjects. In the insulin-withdrawn patients, leucine concentration (259 ± 17 μmol/1), production
rate (2.65 ± 0.29 p mol·min−1 kg−1) and oxidation rate (0.69 ± 0.10 μmol · min−1 · kg−1) were significantly greater (p < 0.001;p < 0.05;p < 0.005 respectively) than corresponding values in control subjects (127±6; 1.81 ± 0.12; 0.19 ± 0.02). Following conventional
insulin therapy, leucine concentration (162 ± 12 μmol/1) and oxidation rate (0.43 ± 0.05 μmol · min−1 · kg−1) were lower than after insulin withdrawal but were still significantly greater than in control subjects (p<0.05;p<0.005). Although leucine concentration, production rate and metabolic clearance rate were normal after an overnight insulin
infusion, leucine oxidation rate was still greater than normal (0.34 ± 0.06 μmol · min−1 kg−1;p<0.05). These results suggest that increased leucine concentration in insulin deficiency is due to elevated leucine production
rate caused by increased proteolysis, and that leucine concentration is restored to normal by insulin treatment. |
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Keywords: | Leucine turnover diabetes insulin protein synthesis leucine oxidation |
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