Generation of chromosome size polymorphism during in vivo mitotic multiplication of Plasmodium berghei involves both loss and addition of subtelomeric repeat sequences |
| |
| Authors: | M Ponzi C J Janse E Dore R Scotti T Pace T J Reterink F M van der Berg B Mons |
| |
| Affiliation: | Laboratorio di Biologia Cellulare, Istituto Superiore di Sanità, Rome, Italy. |
| |
| Abstract: | Extensive chromosome size polymorphism arises in Plasmodium berghei during in vivo mitotic multiplication. Size differences between homologous chromosomes involve rearrangements occurring in the subtelomeric portions while internal chromosomal regions do not contribute significantly to chromosome size polymorphism. Differences in the copy number of a 2.3-kb subtelomeric repeated unit are shown to correlate with size variations, and in at least one case to account completely for the size difference between two variants of the same chromosome. |
| |
| Keywords: | |
|
