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鞘内注射p-MPPF对异氟烷镇痛作用的影响
引用本文:马涛,袁力勇,王丹,戴体俊,郭忠民,张励才.鞘内注射p-MPPF对异氟烷镇痛作用的影响[J].中国药理学通报,2010,26(8).
作者姓名:马涛  袁力勇  王丹  戴体俊  郭忠民  张励才
作者单位:1. 徐州医学院麻醉学院,江苏,徐州,221004
2. 宁波市妇女儿童医院麻醉科,浙江,宁波,315012
基金项目:宁波市自然科学基金资助项目,江苏省高校自然科学基础研究资助项目 
摘    要:目的探讨异氟烷(isoflurane,Iso)镇痛作用与小鼠脊髓5-HT1A受体的关系。方法昆明种小鼠腹腔注射Iso建立镇痛模型。分别以甩尾法、热板法、醋酸扭体法(15min内)评估小鼠鞘内注射5-HT1A受体拮抗剂p-MPPF(6μg和3μg)对Iso镇痛作用的影响。结果单独鞘内注射p-MPPF对小鼠甩尾潜伏期、热板痛阈、扭体次数无影响(P>0.05)。与Iso镇痛组(Iso组)相比,合用药组(Iso+M6组,Iso+M3组)甩尾潜伏期与热板痛阈均缩短(P<0.01或P<0.05);Iso+M6组扭体次数较Iso组增多(P<0.05),Iso+M3组无变化(P>0.05)。结论 Iso体表镇痛作用与激动小鼠脊髓5-HT1A受体密切相关。

关 键 词:异氟烷  镇痛  p-MPPF  5-HT1A受体  甩尾法  热板法  醋酸扭体法  脊髓

Influence of intrathecal injection of p-MPPF on the analgesic effects of isoflurane
MA Tao,YUAN Li-yong,WANG Dan,DAI Ti-jun,GUO Zhong-min,ZHANG Li-cai.Influence of intrathecal injection of p-MPPF on the analgesic effects of isoflurane[J].Chinese Pharmacological Bulletin,2010,26(8).
Authors:MA Tao  YUAN Li-yong  WANG Dan  DAI Ti-jun  GUO Zhong-min  ZHANG Li-cai
Abstract:Aim To investigate the relationship be-tween the analgesic effects of isoflurane ( Iso) and the 5-HT1A receptor in the spinal cord of mice. Methods After the analgesic model of mice was established by intraperitoneal injection ( ip) of Iso,tail-flick test,hotplate test and acetic-acid-writhing test ( during 15 minutes) were used respectively to observe the influence of intrathecal administration 6 μg or 3 μg p-MPPF ( an antagonist of 5-HT1A receptor) on the analgesic effects of Iso. Results Intrathecal administration of p-MPPF alone had no effects on tail-flick latency ( TFL) ,pain threshold in hot-plate test ( HPPT) or writhing times ( WTs) ( P > 0. 05) . Compared with Iso analgesic group ( Iso group) ,the TFL or HPPT of co-administration groups ( Iso + M6 group,Iso + M3 group) shortened ( P <0. 01 or P < 0. 05) ; the WTs of Iso + M6 group increased ( P < 0. 05) whereas that of Iso + M3 group was similar to Iso group ( P > 0. 05) . Conclusion These findings suggest that the surface analgesic effects of Iso are closely related to the excited 5-HT1A receptor in the spinal cord of mice.
Keywords:p-MPPF
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