| 多发性骨髓瘤患者血清IL-6及sIL-6R变化的意义 |
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| 引用本文： | 顾莲芝,卢爱萍,陈宏声,王春红,姜玉珍.多发性骨髓瘤患者血清IL-6及sIL-6R变化的意义[J].吉林大学学报(医学版),2002,28(3):289-290. |
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| 作者姓名： | 顾莲芝 卢爱萍 陈宏声 王春红 姜玉珍 |
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| 作者单位： | 1. 吉林大学第二医院血液科,吉林,长春130041;2. 黑龙江省方正县医院 |
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| 摘 要： | 目的:探讨多发性骨髓瘤(MM)患者血清白细胞介素6(IL-6)及血清可溶性白细胞介素6受体(sIL-6 R)水平及临床意义.方法:联合检测24例MM患者化疗前后血清IL-6及sIL-6 R水平.结果:初诊时血清IL-6及sIL-6 R较正常对照组显著增高(P<0.01).MM患者sIL-6 R水平与疗效及病情活动有关.有效组用药后sIL-6 R明显下降,低于无效组(P<0.01),无效组用药后变化不明显(P>0.05).动态观察发现sIL-6 R水平与骨髓浆细胞比例的变化相一致.结论:初诊MM患者血清IL-6及sIL-6 R较正常对照组显著增高.血清sIL-6 R可作为估计MM疗效、判断预后的指标.
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| 关 键 词： | 多发性骨髓瘤 可溶性白细胞介素-6受体 白细胞介素-6 |
| 文章编号： | 1671-587X(2002)03-0289-02 |
| 修稿时间： | 2001年8月15日 |
The significance of IL-6 and sIL-6R levels in patients with multiple myeloma |
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| Abstract: | Objective:To study the clinical significance of IL 6 and sIL 6R in patients with multiple myeloma (MM).Methods:Serum levels of IL 6 and sIL 6R in patients with MM before and after chemotherapy were measured.Results:Serum levels of IL 6 and sIL 6R in initial patients with MM were significantly higher than that in normal controls ( P <0 01). The levels of IL 6 and sIL 6R were related to response for chemotherapy. The serum levels of sIL 6R in responder group was significantly lower than that in non responder group after chemotherapy ( P <0 01). The serum levels of non responder group changed in significantly after chemotherapy ( P >0 05). Conclusion:Serum levels of IL 6 and sIL 6R were increased signicantly in patients with MM.Thus, serum level of sIL 6R is a indicator to evaluate the response of MM to chemotherapy and to assess the prognosis of a patient with MM. |
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| Keywords: | multiple myeloma interleukin 6 receptor interleukin 6 |
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