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Sporothrix schenckii Lymphadentitis in a Male with X-linked Chronic Granulomatous Disease |
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| Authors: | Jessica R. Trotter Panida Sriaroon David Berman Aleksandra Petrovic Jennifer W. Leiding |
| Affiliation: | 1. Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Children’s Research Institute, University of South Florida, 140-7th Avenue South, Box 7890, St. Petersburg, FL, 33701, USA 2. Division of Infectious Diseases, All Children’s Hospital, 601-5th Street South Suite 504, St. Petersburg, FL, 33701, USA 3. Blood and Marrow Transplant Program, All Children’s Hospital, 601-5th Street South 3rd floor, St. Petersburg, FL, 33701, USA 4. Children’s Research Institute, 140-7th Avenue South, Box 9680, St. Petersburg, FL, 33701, USA |
| Abstract: | Sporothrix schenckii lymphadenitis was identified in a 33 month old male with X-linked chronic granulomatous disease (CGD). S. schenckii is a dimorphic catalase producing fungus found in the soil of temperate and tropical climates. Host defense against S. schenckii relies primarily on innate and cellular responses and gp91phox?/? mice are susceptible to disseminated infection. This case represents the first report of susceptibility to sporotrichosis in a patient with CGD. |
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