黄嘌呤氧化还原酶的表达与胃癌侵袭转移的关系

目的:探讨胃癌中黄嘌呤氧化还原酶(XOR)的表达及其与胃癌侵袭转移的关系,评估其在胃癌中的意义。方法:采用SP免疫组化技术,检测264例胃癌组织标本中XOR的表达水平,研究XOR表达与临床病理参数以及5年生存率之间的关系。结果:XOR在胃癌组织中的阳性表达率明显低于癌旁组织(P<0.01);XOR表达与肿瘤分期、浸润深度、淋巴结状况、肿瘤大小有密切关系(P<0.05)。XOR高表达者5年生存率为47%,XOR低表达者为22%,两者比较,差异有统计学意义(P<0.001)。XOR低表达者预后不良。结论:XOR可能是胃癌具有侵袭生物学特性的一个新的标志物。

Expression of xanthine oxidoreductase and its correlation with tumor invasion and metastasis in gastric carcinoma

Objective To investigate the expression of xanthine oxidoreductase(XOR) and its correlation with tumor invasion and metastasis in gastric carcinoma.Methods Expressions of XOR were measured by immunohistochemistry in 264 gastric carcinoma specimens and corresponding normal tissues,and the correlation between XOR levels and a series of clinicopathological variables,as well as disease-specific survival,was assessed.Results The expression rate of XOR was decreased in gastric cancer as compared with that in the corresponding normal tissues(P < 0.01).The expression of XOR was related to tumor stage,tumour penetration,lymph node metastasis,and tumor size(P < 0.05).Down regulation of XOR was associated with unfavourable outcome,and the cumulative 5-year gastric cancer-specific survival in patients with positive XOR expression was 47%,compared with 22% in those with negative expression(P < 0.001).Conclusions Expression of XOR in gastric carcinoma may be a new marker for identifying a more aggressive gastric carcinoma.