Linkage of a gene for dominant non-syndromic deafness to chromosome 19 |
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| Authors: | Chen, Achih H. Ni, Li Fukushima, Kunihiro Marietta, Jacquie O'Neill, Marsha Coucke, Paul Willems, Patrick Smith, Richard J.H. |
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| Affiliation: | Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of Iowa Iowa City, IA 52242, USA 1Department of Medical Genetics, University of Antwerp, Antwerp, Belgium |
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| Abstract: | Inherited hearing impairment can occur either in the presenceof other clinical features (syndromic hearing loss, SHL) orin isolation (non-syndromic hearing loss, NSHL). The latteris more common and is highly heterogeneous. To date, six NSHLloci have been mapped. We report the identification of a seventhlocus (DFNA4) on chromosome 19q13 and suggest DM kinase as apossible candidate gene. |
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