冠心舒通胶囊治疗冠状动脉慢血流现象的临床疗效研究

目的探讨冠心舒通胶囊治疗冠状动脉慢血流现象(CSFP)的临床疗效。方法选择2011年8月—2013年2月在我院心内科进行治疗的CSFP患者40例,将其随机分成对照组19例和治疗组21例。对照组采用常规辛伐他汀、硝酸酯类、曲美他嗪和阿司匹林治疗,治疗组在对照组基础上加用冠心舒通胶囊。治疗结束后观察患者症状、心电图变化,复查冠状动脉造影观察冠状动脉血流变化,并观察治疗期间不良反应情况。结果临床症状改善:治疗组有效率为76.2%,高于对照组的52.6%(P0.05);心电图疗效:治疗组总有效率为52.4%,与对照组的47.4%比较,差异无统计学意义(P0.05);冠状动脉血流改善:治疗组有效率为61.9%,低于对照组的42.1%(P0.05)。两组均未出现明显不良反应。结论冠心舒通胶囊治疗CSFP虽然对心电图无明显改善,但患者临床症状及冠状动脉血流有改善。

Effect of Guanxinshutong Capsule on Coronary Slow Flow Phenomenon

Objective To investigate the effect of Guanxinshutong capsule on coronary slow flow phenomenon （CSFP）. Methods From August 2011 to February 2013, 40 patients with CSFP in Department of Cardiology in our hospital were chosen, and then they were randomly divided into control group （ n = 19） and treatment group （ n = 21 ）. Control group given simvastatin, nitrates, trimetazidine and aspirin, while treatment group given Guanxinshutong capsule based on the therapy of control group. Improvement of clinical symptoms and ECG were observed, coronary angiography was rechecked to observe the improvement of blood flow of coronary artery, and adverse reactions during treatment were observed. Results Improvement of clinical symptoms ： the effective rate of treatment group was 76. 2%, was higher than that of control group of 52. 6% （ P 〈0. 05） ; improvement of ECG： the total effective rate of treatment group was 52. 4%, that of control group was 47.4%, the difference was not significantly different （ P 〉 0. 05 ） ; improvement of blood flow of coronary artery： the effective rate of treat- ment group was 61.9%, was higher than that of control group of 42. 1% （P 〈 0. 05 ）. No one occurred obvious adverse reac- tions in the two groups. Conclusion Guanxinshutong capsule has certain effect on clinical symptoms and blood flow of coronary artery in patients with CSFP, but can not improve ECG.