Nocturnal feeding pattern in the prepubertal rat: influence of the ventromedial hypothalamus (VMH) |
| |
Authors: | G C Sieck D M Nance R A Gorski |
| |
Affiliation: | 1. Department of Anatomy and Brain Research Institute UCLA School of Medicine, Los Angeles, CA 90024 USA;2. Department of Anatomy University of South Florida, Tampa Florida 33612 USA |
| |
Abstract: | Daily feeding patterns, food intake and changes in body weight of male and female prepubertal rats were observed across a period from 21 to 50 days of age. Light/dark differences in feeding were found for both males and females throughout the recorded period, with feeding occurring predominantly during the dark period. The light/dark difference in feeding behavior gradually increased as the animals developed. Bilateral lesions placed in the VMH of female rats at 21 days of age disrupted the light/dark differences in feeding behavior primarily by decreasing dark period feeding. These lesions further resulted in a period of hypophagia and retarded body weight gain as well as a delay in pubertal onset. These data indicate that prepubertal rats regulate their feeding behavior so that food intake occurs principally during the dark period and that the integrity of the VMH is necessary for this regulation. |
| |
Keywords: | Food intake Feeding patterns Body weight regulation Ventromedial hypothalamus |
本文献已被 ScienceDirect 等数据库收录! |