轻度冠状动脉狭窄患者高尿酸血症影响因素分析

目的探讨轻度冠状动脉狭窄患者合并高尿酸血症的影响因素。方法入选轻度冠状动脉狭窄的患者根据血清尿酸水平分为高尿酸血症组72例（58.5±8.0岁）和血清尿酸正常对照组195例（57.3±9.9岁）。结果单因素分析提示合并高血压病、糖尿病、高体重指数、甘油三酯升高、高密度脂蛋白降低和血清肌酐水平增加是高尿酸血症的危险因素。logistic回归分析提示高尿酸血症与合并糖尿病、体重指数、甘油三酯和血清肌酐呈正相关。结论轻度冠状动脉狭窄患者高尿酸血症与合并糖尿病、高体重指数、高甘油三酯和血清肌酐水平升高密切相关。

A Study of Risk Factors of Hyperuricemia in Patients with Mild Coronary Artery Stenosis

Objective To study the risk factors of hyperuricemia in patients with mild coronary artery stenosis.Methods The clinical data of 267 patients,who underwent coronary angiography,were collected and classified into the hypemdcemia group(58.5±8.0 years)and the normal control group(57.3±9.9 years).The coronary artery diameter stenosis of all the patients was lower than 50%.Results Elevated levels of body mass index(BMI),serum creatinine,triglyceride,low level of high-density lipoprotein,and history of hypertension or diabetes mellitus were significantly correlated with increased prevalence of hyperuricemia in patients with mild coronary artery stenosis.Multivariate logistic regression models found that the risk factors were diabetes mellitus(OR=1.999,95%CI 1.087 to 3.678),BMI(OR=1.110,95%CI 1.009 to 1.221),hypertriglyceridemia(OR=1.237,95%CI 1.023 to 1.496),and scram creatinine(OR=1.026,95%CI 1.008 to 1.045).Conclusion Diabetes mellitus,BMI,hypertriglyceridemia and serum creatinine are independent risk factors of hyperuricemia in patients with mild coronary artery stenosis.