Molecular assays for the detection of prostate tumor derived nucleic acids in peripheral blood |
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| Authors: | Matthias Jost John R Day Ryan Slaughter Theodore D Koreckij Deanna Gonzales Martin Kinnunen Jack Groskopf Harry G Rittenhouse Robert L Vessella Mark A Reynolds |
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| Affiliation: | (1) Gen-Probe Incorporated, San Diego, CA 92121, USA;(2) Department of Urology, University of Washington, Seattle, WA 98195, USA;(3) Puget Sound VA Health Care System, Washington, DC 20420, USA |
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| Abstract: | Background Prostate cancer is the second leading cause of cancer mortality in American men. Although serum PSA testing is widely used for early detection, more specific prognostic tests are needed to guide treatment decisions. Recently, the enumeration of circulating prostate epithelial cells has been shown to correlate with disease recurrence and metastasis following definitive treatment. The purpose of our study was to investigate an immunomagnetic fractionation procedure to enrich circulating prostate tumor cells (CTCs) from peripheral blood specimens, and to apply amplified molecular assays for the detection of prostate-specific markers (PSA, PCA3 and TMPRSS2:ERG gene fusion mRNAs). |
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