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Formulation of fenbufen suppositories. I. quantitative histological assessment of the rectal mucosa of rats following treatment with suppository bases |
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| Authors: | A. S. Reid N. W. Thomas K. J. Palin P. L. Gould |
| Affiliation: | a Departments of Human Morphology University of Nottingham, Nottingham, U.K. b Departments of Pharmacy, University of Nottingham, Nottingham, U.K. c Departments of Product Research and Development Laboratories Cyanamid of Great Britain Ltd., Gosport, Hampshire, U.K. |
| Abstract: | Quantitative histology was used to assess the interaction of suppositories of hard fats (Suppocire AP and OS1X; Witepsol H12 and H19) and polyethylene glycol (PEG 1500) with the rectal mucosa of rats. All bases significantly increased epithelial cell loss but only following PEG treatment was the natural capacity of the epithelium to resist disruption exceeded, thereby resulting in areas of complete desquamation with a bare basal lamina. On the basis of these data it was possible to rank the interaction of the suppositories with the rectal lining; Suppocire OS1X < Suppocire AP = Witepsol H12 < H19 < PEG 1500. |
| Keywords: | Suppository Base Qualitative histology Rat |
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