| 6号染色体微卫星标记与精神分裂症的连锁不平衡研究 |
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| 引用本文： | 邓红,刘协和,蔡贵庆,Henry Terwedow,王朝羲,徐欣. 6号染色体微卫星标记与精神分裂症的连锁不平衡研究[J]. 中华医学遗传学杂志, 2002, 19(1): 6-9 |
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| 作者姓名： | 邓红 刘协和 蔡贵庆 Henry Terwedow 王朝羲 徐欣 |
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| 作者单位： | 1. 四川大学华西医院心理卫生研究所,成都,610041
2. Program for Population Genetics, Harvard School of Public Health, U S A(Henry Terwedow |
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| 摘 要： | 目的 探索6号染色体的有关微卫星标记与精神分裂症的关系。方法 对115个精神分裂症同胞及核心家系，按照不同的诊断分类，以分布于6号染色体的28个微卫星标记，进行连锁不平衡研究，并分别按照阳性和阴性症状量表及发病年龄分成不同的亚组，在不同的亚组中进行连锁不平衡分析。以XDT和MAPMAKER／SIBS软件系统完成所有连锁不平衡关系具有显著性意义，P值均小于0.005。在以各项PANSS量表和不同发病年龄所分亚组的分析中表明，只有D6S1960位点与精神分裂症的连锁不平衡关系值始终具有显著性意义（P＜0.05）。结论 6号染色体短臂D6S1960附近可能存在精神分裂症的易感基因。
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| 关 键 词： | 精神分裂症 6号染色体 连锁不平衡 |
| 修稿时间： | 2001-04-17 |
Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia |
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| Henry Terwedow. Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia[J]. Chinese journal of medical genetics, 2002, 19(1): 6-9 |
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| Authors: | Henry Terwedow |
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| Affiliation: | Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. xieheliu@hotmail.com |
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| Abstract: | Objective To explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis. Methods Twenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system. Results Significant P value ( P <0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value ( P <0.05) in all the subgroups divided by PANSS scale and the age of onset. Conclusion The area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia. |
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| Keywords: | schizophrenia chromosome 6 linkage disequilibrium |
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