| 21-氨基类固醇类药物U-74389G对创伤性脑水肿的影响 |
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| 引用本文： | 于明琨,江基尧,杨中坚,卢亦成,陈世文.21-氨基类固醇类药物U-74389G对创伤性脑水肿的影响[J].第二军医大学学报,1999,20(8):565-567. |
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| 作者姓名： | 于明琨 江基尧 杨中坚 卢亦成 陈世文 |
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| 作者单位： | 第二军医大学长征医院神经外科 |
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| 摘 要： | 目的：探讨２１－氨基类固醇类药物Ｕ－７４３８９Ｇ对脑外伤后脑水肿和离子含量的影响。方法：分别采用干／湿质量法测定伤后脑含量，原子吸收光谱分析法测定脑组织内离子含量。结果：伤侧脑组织含水量外伤组较对照组显著增加，但治疗组含不量比外伤组又显著降低。Ｎａ＾＋、Ｃａ＾２＋含量外伤组较对照组明显增加，但治疗组比外伤组显著降低；Ｋ＾、Ｍｇ２＋含量外伤组较对照组明显降低，但治疗组较外伤组有不同程度的升高。结论：
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| 关 键 词： | 21－氨基类固醇 脑水肿 颅脑损伤 U－74389G |
Effect of 21-aminosteroid (U-74389G) on brain edema post traumatic brain injury in rats |
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| Chen Shiwen,Lu Yicheng,Yang Zhongjian,Jiang Jiyao,Yu Mingkun.Effect of 21-aminosteroid (U-74389G) on brain edema post traumatic brain injury in rats[J].Academic Journal of Second Military Medical University,1999,20(8):565-567. |
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| Authors: | Chen Shiwen Lu Yicheng Yang Zhongjian Jiang Jiyao Yu Mingkun |
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| Abstract: | Objective: To explore the effect of 21 aminosteroid (U 74389G) on brain edema post traumatic brain injury (TBI) in rats. Methods: Water content of brain after TBI was assayed by means of dry/wet weight methodology, and the content of ion was measured by an atom absorption spectrum analysis apparatus. Results: The turbulence of sodium, potassium, calcium and magnesium after TBI could be alleviated by U 74389G. The increased water content of injured brain tissue could also be alleviated by the administration of U 74389G. Conclusion: The study indicates that U 74389G could effectively improve brain edema after TBI. |
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| Keywords: | 21-aminosteroid brain edema |
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