妊娠高血压综合征免疫学发病机制的研究

目的：研究妊娠高血压综合征（妊高征）的免疫学发病机制。方法：通过检测妊高征患者及正常孕妇蜕膜组织细胞培养上清液中白细胞介素－１（ＩＬ－１）、白细胞介素－２（ＩＬ－２）和肿瘤坏死因子－α（ＴＮＦ－α）的活性，分析蜕膜免疫细胞因子的变化与妊高征之间的关系。结果：与正常孕妇相比，妊高征患者蜕膜组织中ＩＬ－１、ＩＬ－２和ＴＮＦ－α的分泌显著升高。结论：蜕膜组织免疫微环境中细胞因子的改变可能是妊高征发病的机制之一

Study on the immunological pathogenesis of pregnancy induced hypertension.

Objectives:To investigate the immunological pathogenesis of pregnancy induced hypertension (PIH).Methods:To determine the concentration of interleukin 1(IL-1),interleukin 2(IL-2),and tumor necrosis factor alpha(TNF-α) in cultured decidual tissue cell supernatant of normal gravidas and patients with PIH,and to analyse the relationship between the changes of cytokines and PIH.Results:Compared with the normal controls,the levels of IL 1,IL 2,and TNF-α in patients with PIH were elevated signifancantly.Conclusion:The changes of cytokines in decidual tissues may play an important role in immunological pathogenesis in PIH.