孕妇血清中抗心磷脂抗体水平对围产儿的影响

目的：探讨孕妇血清抗心磷脂抗体（ａｎｔｉｃａｒｄｉｏｌｉｐｉｎａｎｔｉｂｏｄｙ，ＡＣＡ）水平增高对围产儿的影响。方法：用酶联免疫吸附法（ＥＬＩＳＡ）测定２０８份健康孕妇的血清ＡＣＡ－ΙｇＡ、ＩｇＧ和ＩｇＡ结合指数，观察ＡＣＡ水平与小于胎龄儿、胎儿窘迫及新生儿窒息的关系。结果：小于胎龄儿组和围产儿缺氧组的ＡＣＡ－ＩｇＭ、ＩｇＡ结合指数显著高于对照组（Ｐ＜０．００１～Ｐ＜０．０５），而ＡＣＡ－ＩｇＧ结合指数差异无显著性（Ｐ＞０．２）；小于胎龄儿组的ＡＣＡ－ＩｇＡ结合指数显著高于围产儿缺氧组（Ｐ＜０．０２），但ＡＣＡ－ＩｇＭ和ＩｇＧ结合指数差异无显著性（Ｐ＞０．１，Ｐ＞０．５）；胎儿窘迫、新生儿窒息及胎儿窘迫合并新生儿窒息时，孕妇血清ＡＣＡ－ＩｇＭ、ＩｇＡ和ＩｇＧ结合指数差异无显著性（Ｐ＞０．０５）。结论：孕妇血清中的ＡＣＡ水平增高对围产儿预后具有显著的不良影响

Effect of maternal serum anticardiolipin antibody on perinatal fetus.

Objective:To evaluate the effects of maternal seurm anticardiolipin antibody(ACA)on perinatal fetus.Methods:Maternal serum ACA IgM,IgA and IgG binding indexes were determined using ELISA in 208 healthy pregnant women.These subjects were divided into three groups:control,small for gestational age(SGA)and perinatal anoxia(PA)which was defined as fetal distress(FD) and/or neonatal asphyxia(NA).Results:When compared with control group,ACA IgM and IgA binding indexes increased significantly in both SGA and PA groups(P<0.001￣P<0.05),but in ACA group,IgG binding indexes did not increase significantly(P>0.2).ACA IgA binding index in SGA group was significantly higher than that in PA group(P<0.02),but no significant differences of ACA IgM and IgG binding indexes existed between SGA and PA groups(P>0.1 and P>0.5,respectively).No significant differences were found among binding indexes of women with FD,NA and FD complicated with NA groups(P>0.05).Conclusion:Maternal serum ACA abnormality affects perinatal fetus adversely.