孕妇血清中抗心磷脂抗体水平对围产儿的影响 |
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引用本文: | 董Min岳 王正平.孕妇血清中抗心磷脂抗体水平对围产儿的影响[J].现代妇产科进展,1998,7(3):223-226. |
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作者姓名: | 董Min岳 王正平 |
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作者单位: | 浙江医科大学附属妇产科医院 |
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摘 要: | 目的:探讨孕妇血清抗心磷脂抗体(anticardiolipinantibody,ACA)水平增高对围产儿的影响。方法:用酶联免疫吸附法(ELISA)测定208份健康孕妇的血清ACA-ΙgA、IgG和IgA结合指数,观察ACA水平与小于胎龄儿、胎儿窘迫及新生儿窒息的关系。结果:小于胎龄儿组和围产儿缺氧组的ACA-IgM、IgA结合指数显著高于对照组(P<0.001~P<0.05),而ACA-IgG结合指数差异无显著性(P>0.2);小于胎龄儿组的ACA-IgA结合指数显著高于围产儿缺氧组(P<0.02),但ACA-IgM和IgG结合指数差异无显著性(P>0.1,P>0.5);胎儿窘迫、新生儿窒息及胎儿窘迫合并新生儿窒息时,孕妇血清ACA-IgM、IgA和IgG结合指数差异无显著性(P>0.05)。结论:孕妇血清中的ACA水平增高对围产儿预后具有显著的不良影响
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关 键 词: | 抗心磷脂抗体 围产儿 预后 |
Effect of maternal serum anticardiolipin antibody on perinatal fetus. |
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Abstract: | Objective:To evaluate the effects of maternal seurm anticardiolipin antibody(ACA)on perinatal fetus.Methods:Maternal serum ACA IgM,IgA and IgG binding indexes were determined using ELISA in 208 healthy pregnant women.These subjects were divided into three groups:control,small for gestational age(SGA)and perinatal anoxia(PA)which was defined as fetal distress(FD) and/or neonatal asphyxia(NA).Results:When compared with control group,ACA IgM and IgA binding indexes increased significantly in both SGA and PA groups(P<0.001 ̄P<0.05),but in ACA group,IgG binding indexes did not increase significantly(P>0.2).ACA IgA binding index in SGA group was significantly higher than that in PA group(P<0.02),but no significant differences of ACA IgM and IgG binding indexes existed between SGA and PA groups(P>0.1 and P>0.5,respectively).No significant differences were found among binding indexes of women with FD,NA and FD complicated with NA groups(P>0.05).Conclusion:Maternal serum ACA abnormality affects perinatal fetus adversely. |
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Keywords: | Anticardiolipin antibody Perinatal fetus Prognosis |
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