妊娠高血压综合征孕妇血浆一氧化氮和内皮素的变化及其意义

目的：探讨一氧化氮（ＮＯ）和内皮素（Ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）在妊高征发病中的变化及其病理意义。方法：用分光光度法和放射免疫法分别定量检测正常妊娠３０例（对照组）和妊高征３７例（妊高征组）血浆ＮＯ和ＥＴ的变化。结果：妊高征组血浆ＮＯ水平低于对照组（Ｐ＜０．０１），ＥＴ水平则高于对照组（Ｐ＜０．０１）；妊高征组分娩前后相比，ＮＯ水平分娩后升高（Ｐ＜０．０１），ＥＴ水平则下降（Ｐ＜０．０１），ＮＯ、ＥＴ呈显著负相关（Ｐ＜０．０１），ＮＯ、ＥＴ与平均动脉压均有显著相关性（Ｐ＜０．０１）。结论：ＮＯ与ＥＴ在妊高征的发病机制中有重要作用，ＥＴ／ＮＯ失衡可以反映妊高征的病变程度，其病理变化在某种程度上呈可逆性。

The changes and significance of plasma natric oxide and endothelin in patients with pregnancy induced hypertension.

Objective:To investigate the changes and significance of plasma nitrous oxide(NO) and endothelin(ET) level in patients with pregnancy induced hypertension(PIH).Methods:Using spectrophotometric method and radioimmunoassay,the changes of NO and ET of 30 normal pregnant women and 37 women with PIH were determired.Results:The plasma NO levels of women with PIH was lower than that of the control group( P <0.01),while the plasma ET levels of women with PIH was higher than that of the control group( P <0.01);the antepartum plasma NO of the women with PIH was higher than that of postpartum one( P <0.01);the ET levels of the postpartum deline( P <0.01),the plasma NO was negative correlation with the plasma ET( P <0.01),the plasma NO and ET were a significant correlation with mean arterial pressure( P < 0.01 ).Conclusion:The plasma NO and ET are paly an important role for PIH etiopathology,the imhalance of ET/NO may show that the situation of pathological changes in patient with PIH is riversible.