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Abolition of neurally evoked motor responses of the vas deferens by 6-hydroxydopamine
Authors:R M Wadsworth
Affiliation:Department of Pharmacology, University of Strathclyde, Glasgow, G1 1XW, Scotland
Abstract:Contractions of isolated guinea-pig or rat vasa deferentia evoked by stimulation through ring electrodes were abolished after incubation with 6-hydroxydopamine?HBr. After this treatment it was no longer possible to demonstrate the presence of fluorescent nerves by the Falk-Hillarp technique and most preparations became supersensitive to noradrenaline. It is concluded that the motor innervation of rat and guinea-pig vasa deferentia is noradrenergic.
Keywords:6-Hydroxydopamine  Fluorescence microscopy  Innervation of the vas deferens
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