CD44v6与胃癌淋巴结转移及预后关系研究

目的探讨CD44v6与胃癌淋巴结转移及预后的关系。方法采用免疫组织化学方法检测208例胃癌组织和相应癌旁组织中CD44v6蛋白的表达情况，分析CD44v6与胃癌淋巴结转移及预后之间的关系。结果CD44v6在胃癌中的表达率（59.1％）明显高于癌旁组织（0）。CD44v6表达阳性与阴性患者术后5年生存率分别为38.8%和76.3%，差别有统计学意义（P＜0.05）。多因素分析提示，CD44v6高表达为胃癌的独立预后因素；CD44v6和浸润深度是淋巴结转移的独立危险因素。分层分析发现，淋巴结有转移者CD44v6表达阳性与阴性的5年生存率分别30.3%和67.7%（P＜0.05），淋巴结无转移者CD44v6表达阳性与阴性的5年生存率分别77.3%和81.8%（P＞0.05）。结论CD44v6表达阳性的胃癌患者易发生淋巴结转移，预后较差；CD44v6可能成为预测胃癌预后指标之一。

The Expression and Clinical Value of CD44v6 in Gastric Cancer

ObjectiveTo investigate the relationship between CD44v6 and the lymph node metastasis as well as the prognosis of gastric cancer.MethodsThe expression level of CD44v6 protein in cancerous tissues and the corresponding non-cancerous tissues in 208 patients with gastric cancer was measured by immunohistochemistry, followed by analysis of the relevance between CD44v6, lymph nodes metastasis and the prognosis of gastric cancer.ResultsThe expression level of CD44v6 in gastric cancer was 59.1%, which was significantly higher than the 0% detected in the paired non-tumor tissues.The 5-year survival rate in patients with positive and negative CD44v6 expression was 38.8% and 76.3%, respectively, with the difference being statistically significant (P<0.05).Multivariate analysis demonstrated that high expression of CD44v6 was the independent prognostic factor of gastric cancer, while CD44v6 and the depth of tumor invasion were the independent risk factors for lymph nodes metastasis.Stratification analysis revealed that in patients with lymph nodes metastasis, the 5-year survival rate of positive and negative CD44v6 expression was 30.3% and 67.7%, respectively, whereas in non-metastasized cases, the rate was 77.3% and 81.8% (P<0.05).ConclusionPatients with high expression level of CD44v6 are susceptible to lymph nodes metastasis, leading to poor outcomes.CD44v6 can be identified as a biomarker for predicting the prognosis of gastric cancer.To investigate the relationship between CD44v6 and the lymph node metastasis as well as the prognosis of gastric cancer.MethodsThe expression of CD44v6 protein level in 208 cases of gastric cancer and the corresponding non-cancerous tissues was detected by immunohistochemistry, followed by the analysis of the relevance between CD44v6, lymph nodes metastasis and the prognosis of gastric cancer.ResultsThe expression level of CD44v6 in gastric cancer was 59.1%, which was significantly higher than the 0% detected in the paired non-tumor tissues.The 5-year survival rate in patients with positive and negative CD44v6 expression was 38.8% and 76.3%, respectively, with the difference being statistical significant (P<0.05).Multivariate analysis demonstrated that high expression of CD44v6 was the independent prognostic factor of gastric cancer, while CD44v6 and the depth of tumor invasion were the independent risk factors for lymph nodes metastasis.Stratification analysis revealed that in patients with lymph nodes metastasis, the 5-year survival rate of positive and negative CD44v6 expression was 30.3% and 67.7%, respectively, whereas in non-metastasized cases, the rate was 77.3% and 81.8% (P<0.05).ConclusionPatients with high expression level of CD44v6 were prong to lymph nodes metastasis, leading to poor outcomes.CD44v6 can be identified as a biomarker for predicting the prognosis of gastric cancer.