Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study |
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Authors: | Kyung-Jae Lee Manami Inoue Tetsuya Otani Motoki Iwasaki Shizuka Sasazuki Shoichiro Tsugane JPHC Study Group |
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Institution: | (1) Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, 104-0045 Tokyo, Japan;(2) Department of Preventive Medicine, Soonchunhyang University College of Medicine, Seoul, Korea |
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Abstract: | Objective To prospectively examine the association between physical activity and the risk of developing colorectal cancer in a large
population-based cohort study of Japanese men and women, and to investigate whether the effects of physical activity on colorectal
cancer risk differ by sex and subsite.
Methods We analyzed data from a population-based cohort of 65,022 subjects. A total of 486 incident colorectal cancers (154 proximal
colon, 166 distal colon and 149 rectal cancers) was identified during 6 years of follow-up.
Results We observed a significant inverse association between physical activity and the risk of developing colorectal cancer, particularly
colon cancer, among men. Relative to men in the lowest level of metabolic equivalent (MET) hours per day, those in the highest
level had a RR of 0.69 (95% CI = 0.49–0.97). A significant decrease in risk of colorectal cancer was associated with increasing
MET hours per day among men. This inverse association was essentially limited to colon cancer. A significant decrease in risk
with increasing MET-hour score was observed predominantly for proximal colon cancer among men. In contrast, no significant
decrease was seen among women.
Conclusion These findings suggest that physical activity may prevent colon cancer among Japanese men.
Study group members are listed in the Appendix at the end of this article. |
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Keywords: | Colorectal cancer Physical activity Prospective study Japan |
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