亚临床甲状腺功能减退症患者血脂、血糖和血尿酸变化分析

目的分析60例亚临床甲状腺功能减退症(亚临床甲减)患者血脂、血糖、血尿酸水平变化及其临床意义。方法测定60例亚临床甲减患者的血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、血糖(GLU)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)水平,并据TSH浓度分为Ⅰ亚组(TSH<10.0 mIU/L)和Ⅱ亚组(TSH≥10.0 mIU/L),分别与56例健康对照组比较及行亚组间比较。结果与健康对照组比较,亚临床甲减组及2个亚组的TSH、TC、TG、LDL-C、UA水平明显升高,而HDL-C明显下降,有显著性差异(P均<0.05),尤以Ⅱ亚组的TC、TG、LDL-C、UA升高最明显(P均<0.01);2个亚组间的TC、TG、LDL-C、UA、HDL-C水平也有显著性差异(P均<0.05);而血糖水平虽有轻微下降,但均无显著性差异。结论亚临床甲减组及2个亚组的TC、TG、LDL-C、HDL-C、UA水平有明显差异,而血糖变化则无显著性差异。亚临床甲减在促进动脉粥样硬化的过程中,血脂代谢紊乱和高尿酸血症可能是重要的危险因素,而与血糖变化无关。

Analysis of the variety of lipids,plasma glucose,blood uric acid in patients with subclinical hypothyroidism

Objective It is to analyze the variety and the clinic signification of lipids,plasma glucose,blood uric acid in patients with subclinical hypothyroidism.Methods The levels of TSH,FT3,FT4,FPG,TC,TG,LDL-C,HDL-C and UA were measured in 60 patients with subclinical hypothyroidism.The patients were divided into two groups according to TSH level: sub-groupⅠ(TSH<10.0 mIU/L) and sub-groupⅡ(TSH≥10.0 mIU/L),then,compared with 56 control subjects,and compared with each other.Results Compared with control subjects,patients with subclinical hypothyroidism,as well as patients with that two groups had higher TSH,TC,TG,LDL-C,UA;and lower HDL-C(P<0.05).Especially,the sub-group Ⅱ had higher TC,TG,LDL-C and UA(all P<0.01).Both sub-groupⅠ and sub-groupⅡ showed a significant difference in TC,TG,LDL-C,UA,HDL-C(P<0.05),FPG were no different.Conclusion Both group of subclinical hypothyroidism and two sub-groups show a significant difference in TC,TG,LDL-C and UA,except FPG.Within subclinical hypothyroidism patients,lipid dysfunction and high uric acid may be important risk factors for the development of atherosclerotic cardiovascular disease,there is no correlation with PFG.