| 甘草酸二铵对缺血再灌注诱导的脑神经细胞凋亡的影响 |
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| 引用本文： | 刘亚军,陈金和,李立中,吴基良.甘草酸二铵对缺血再灌注诱导的脑神经细胞凋亡的影响[J].咸宁医学院学报,2002,16(2):92-94. |
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| 作者姓名： | 刘亚军 陈金和 李立中 吴基良 |
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| 作者单位： | [1]武汉大学基础医学院，武汉430071 [2]药理学教研室 |
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| 摘 要： | 目的：观察甘草酸二铵（dammonii glycyrrhizinatis,DG)对局灶性脑缺血再灌注诱导的脑神经细胞凋亡的防治作用，并探讨其神经保护作用的机制。方法：雄性witar大鼠分为3组，假手术组（sham组），缺血再灌注组（IR组），给药组（DG组），采用大脑中动脉栓塞模型（MCAO），缺血2h再灌注12h，24h后，分别观察脑组织超微结构，脑神经细胞凋亡情况，结果：与IR组相比，DG组脑组织病理损害明显减轻，神经细胞凋亡减少。结论：DG可明显抑制局灶性脑缺血－再灌注所诱导的脑神经细胞凋亡，起到一定的社会保护作用。
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| 关 键 词： | 缺血再灌注 神经细胞凋亡 甘草酸二铵 局灶性脑缺血 神经保护 |
| 文章编号： | 1008-0635(2002)02-0092-03 |
| 修稿时间： | 2002年3月12日 |
The Effect of Dammonii Glycyrrhizinatis on Cerebral Nerve Cell Nerve Cell Apoptosis Induced by Ischemia-Reperfusion |
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| LIU Ya jun ,CHEN Jin he ,LI Li zhong ,et al.The Effect of Dammonii Glycyrrhizinatis on Cerebral Nerve Cell Nerve Cell Apoptosis Induced by Ischemia-Reperfusion[J].Journal of Xianning Medical College,2002,16(2):92-94. |
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| Authors: | LIU Ya jun CHEN Jin he LI Li zhong |
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| Institution: | LIU Ya jun 1,CHEN Jin he 2,LI Li zhong 3,et al |
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| Abstract: | Objective To observe the effect of Dammnii Glycyrrhizinatis (DG) on cerebral nerve cell apoptosis induced by ischemia-reperfusion.Methods Male wistar rats were randomly divided into the sham operated,cerebral ischemia reperfusion (IR) and DG treatment groups.The animal models were estabilished by middle cerebral artery occlusion (MCAO) in rats.The ultrastructure of brain tissue and nerve cell apoptosis were respectirely observed at 12h and 24h after MCAO for 2h.Results Compared with IR group,in DG group the pathological damage of brain tissue and nerve cell apoptosis were diminishcd.Conclusion DG can markedly inhibit nerve cell apoptosis induced by focal brain ischemia reperfusion injury and protect the nerve cell to a certain extent. |
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| Keywords: | Ischemia reperfusion Nerve cell apoptosis DG |
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