Thiazolo[3,2-a]pyrimidine derivatives as calcium antagonists. |
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| Authors: | A Balkan S Uma M Ertan W Wiegrebe |
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| Affiliation: | Department of Pharmaceutical Chemistry, Hacettepe University, Faculty of Pharmacy. |
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| Abstract: | Some new thiazolo[3,2-a]pyrimidine derivatives were prepared refluxing 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives with phenacyl bromide in glacial acetic acid. Calcium antagonistic activities of these compounds were evaluated in K(+)-depolarized rat aorta, using nifedipine as reference compound. |
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