Head-twitch response induced by tyramine |
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Authors: | Syuzo Orikasa Shinobu Sakurada Kensuke Kisara |
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Affiliation: | (1) Department of Chemical Pharmacology, Tohoku College of Pharmacy, Komatsushima, 983 Sendai, Japan |
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Abstract: | The intracerebroventricular (IC) administration of tyramine (TyA) induced a characteristic head-twitch response in mice pretreated with safrazine, a monoamine oxidase inhibitor. Safrazine-pretreated mice exhibited similar head-twitches following the IC treatment of serotonin (5-HT). The maximum dose of 5-HT which did not elicit head-twitches significantly potentiated TyA-induced head-twitches. Antiserotonergic drugs such as morphine and dimethothiazine antagonized TyA-induced head-twitches. A serotonergic denervator, 5,6-dihydroxytryptamine, potentiated head-twitch induced by TyA or 5-HT. Both TyA-induced and 5-HT-induced head-twitches were inhibited by dopamine and noradrenaline, while catecholaminergic denervators such as reserpine and 6-hydroxydopamine, and diethyldithiocarbamic acid, a dopamine--hydroxylase inhibitor, increased the TyA response. These results indicate that head-twitches induced by TyA may be mediated via the serotonergic system and may inhibit the catecholaminergic system. |
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Keywords: | Head-twitches Tyramine Serotonin Safrazine 6-Hydroxydopamine 5,6-Dihydroxytryptamine |
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