Antipyretic, analgesic and anti-inflammatory effects of delta 9-tetrahydrocannabinol in the rat |
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Authors: | D S Kosersky W L Dewey L S Harris |
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Institution: | Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514, U.S.A. |
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Abstract: | The effects on body temperature produced by graded doses of Δ9-tetrahydrocannabinol (Δ9-THC) and phenylbutazone were compared in both normal and pyretic rats. Dose related hypothermic responses were produced by the oral administration of Δ9-THC in normal animals. Moreover, Δ9-THC significantly reduced elevated temperatures in yeast-induced pyretic rats to near normal levels at doses which exhibited little hypothermic activity in normal rats. The oral antipyretic potency of Δ9-THC was approximately 2 times that of phenylbutazone. The comparative oral antinociceptive activity of Δ9-THC and selected narcotic and non-narcotic analgesics was determined by the increase in response latency to pressure applied to normal and yeast-inflamed paws. Δ9-THC administered orally was essentially inactive at dose levels below those producing pronounced central nervous system depression. The oral anti-inflammatory efficacy of Δ9-THC was compared to phenylbutazone and acetylsalicylic acid. Δ9-THC was ineffective in inhibiting carrageenin-induced edema of the rat paw following acute or chronic administration. |
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Keywords: | Antipyretic activity Analgesic activity Anti-inflammatory activity 1464 1468 V 2 |
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