骨形态发生蛋白与载体材料的相关性研究

目的：基于骨形态发生蛋白与载体材料的关系进行综合分析，为从事骨形态发生蛋白各项研究的人员提供参考。资料来源：主要应用计算机检索1990—01／2004—12CNKI及中国期刊全文数据库的文献，检索词为“骨形态发生蛋白，载体材料”，限定的文章语言种类为中文。同时检索1990—01／2004—12Medline数据库的文献，检索词为“Bone morphogenetic protein”，限定文章语言为English。资料选择：对资料进行初审，选择骨形态发生蛋白与载体材料研究有关的文献查找全文一排除重复性的研究文章。资料提炼：共收集63篇关于骨形态发生蛋白与载体材料相关的文献，通过阅读摘要或全文对文章内容进行分类整理，22篇与本文综述内容有关，排除41篇。资料综合：①骨形态发生蛋白的细胞学机制可分为4个时期：趋化期、分化期、骨质形成期、骨质再建期。②骨形态发生蛋白与载体材料所构成的释放系统：骨形态发生蛋白和载体材料的复合使用，既能保留载体材料原有的骨传导作用又加入了诱导骨生成的因子，还能通过建立一个骨形态发生蛋白的缓慢释放系统，使其能在植入部位缓慢释放而持续发挥作用，进一步增强骨诱导能力。③目前值得研究的一些骨形态发生蛋白载体分类：包括胶原材料、生物陶瓷骨修复材料、脱钙骨基质、合成聚合物材料、基因载体。④骨形态发生蛋白-载体的实验：骨形态发生蛋白-载体可以促进骨缺损或骨不连的愈合；骨形态发生蛋白亦能刺激脊柱融合、缩短脊柱融合的时间及改善融合植骨块的生物力学特征：对软骨组织的形成、生长和损伤的修复具有促进作用。结论：正确了解骨形态发生蛋白与载体材料的关系，可以更有效的发挥骨形态发生蛋白在骨科疾病中的治疗作用。

Correlation of bone morphogenetic protein and carrier

OBJECTIVE： To comprehensively analyze the connection between bone morphogenetic protein and carrier so as to provide reference for researchers in field of bone morphogenetic protein.
DATA SOURCES： The computer search of China National Knowledge Infrastructure （CNKI） and China Journal Full-text Database （CJFD） was performed to retrieve articles published from January 1990 to December 2004 with the key words of ＂bone morphogenetic protein, carrier＂ in Chinese. Meanwhile, we retrieved Medline database to search related English articles published froln January 1990 to December 2004 with the key words of ＂bone morphogenetic protein＂ in English.
STUDY SELECTION： The data were checked firstly, articles in accordance with bone morphogenetic protein and carrier were selected, and then the full-texts were searched, the reproducible ones were excluded.
DATA EXTRACTION： Totally 63 articles about bone morphogenetic protein and carrier were collected. The contents of articles were classified and arranged by means of reading the abstracts and full texts. Twenty-two articles were accorded with the criterion, and 41 articles were excluded.
DATA SYNTHESIS： （1） Cytology mechanism of bone morphogenetic protein divided into four phases： chemotaxis phase, differentiation phase, sclerotized phase and sclerotin reconstruction phase. （2）The releasing systeln of constitution of bone morpbogenetic protein and carrier： Multiplicity usage of bone morphogenetic protein and carrier not only kept the original bone conduction of carrier, but also added with factor leading to osteogeny so as to relief slowly at implanted part and play roles persistently and strengthen the bone inductive ability by establishing slow release systeln of bone morphogenetic protein. （3） Classification of worthwhile study of bone morphogenetic protein included collagen material, bioceramic bone reparation material, decalcified bone matrix, synthetic polymer material and genetic carrier. （4）Experiment research of the