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| 宁肠汤对肠易激综合征大鼠下丘脑-垂体-肾上腺轴干预作用研究 | |
| 引用本文： | 石君杰,王海云,邵国民. 宁肠汤对肠易激综合征大鼠下丘脑-垂体-肾上腺轴干预作用研究[J]. 中国中西医结合消化杂志, 2006, 14(2): 93-95 |
| 作者姓名： | 石君杰 王海云 邵国民 |
| 作者单位： | 1. 浙江医学高等专科学校,医学一系内科教研室,浙江,杭州,310053 2. 浙江省立同德医院,儿科,浙江,杭州,310012 3. 浙江中医学院附属医院,检验科,浙江,杭州,310006 |
| 基金项目： | 浙江省中医药管理局科研项目 |
| 摘 要： | [目的]探讨宁肠汤对肠易激综合征(IBS)大鼠神经内分泌功能的调节作用.[方法]以夹尾、束缚刺激作为应激原复制IBS大鼠模型,采用放免法检测模型大鼠下丘脑-垂体-肾上腺(HPA)轴功能,观察宁肠汤的调节作用.[结果]IBS大鼠HPA轴兴奋亢进,皮质醇、促肾上腺皮质激素水平明显升高(P＜0.01).而宁肠汤能降低皮质醇、促肾上腺皮质激素的水平,抑制HPA轴的兴奋性.[结论]宁肠汤对应激引起的的神经内分泌功能紊乱有一定的调节作用. |
| 关 键 词： | 肠易激综合征 下丘脑-垂体-肾上腺轴 宁肠汤 |
| 文章编号： | 1671-038X（2006）02-0093-03 |
| 收稿时间： | 2005-10-21 |
| 修稿时间： | 2005-10-21 |
Regulation of Ningchang decoction on hypothalamus-pitutary-aderenal gland axis(HPAA) of stressed IBS rats |
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| SHI Jun-jie,WANG Hai-yun,SHAO Guo-min. Regulation of Ningchang decoction on hypothalamus-pitutary-aderenal gland axis(HPAA) of stressed IBS rats[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2006, 14(2): 93-95 | |
| Authors: | SHI Jun-jie WANG Hai-yun SHAO Guo-min |
| Affiliation: | 1.First Medical Department, Zhejiang Medical College, Hangzhou 310053, China; 2.Pediatric Department, Zhejiang Tongde Hospital, Hangzhou 310012, China; 3. Clinical Laboratory, Zhejiang TCM College Affiliated Hospital, Hangzhou 310006, China |
| Abstract: | [Objective] To investigate the regulation of Ningchang decoction(ND) on neuroendocrine function of stressed IBS rats.[Methods] The stressed IBS rat model was made by chronic binding stress and nipping the tail.RIA was adopted to measure the function of hypothalamus-pitutary-adrenal gland axis(HPAA) of stressed IBS rats.The regulation of ND was observed.[Results] Stress increased the contents of serum corticotropin and adrenocortictropin homone(ACTH)(P<0.01),which suggested that the excitabity of HPAA was enhanced.While ND could decrease HPAA excitability of stressed IBS rats.[Conclusion]ND could regulate the disorder of neuroendocrine-function of stressed IBS rats. |
| Keywords: | irritable bowel syndrome(IBS) hypothalamus-pitutary-adrenal gland axis(HPAA) Ningchang decoction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |