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| 铀促排药物研究VⅢ:邻苯二酚类鳌合剂的新法合成 | |
| 引用本文： | 覃兆海,谢毓元.铀促排药物研究VⅢ:邻苯二酚类鳌合剂的新法合成[J].药学学报,1994,29(12):929-933. |
| 作者姓名： | 覃兆海 谢毓元 |
| 作者单位： | *北京农业大学应用化学系,北京100094;中国科学院上海药物研究所,上海200031 |
| 摘 要： | In further study on the synthesis of chelating agents with catechol residue,twoconvenient procedures-ethyl chloroformate method and dicyclohexylcarbodiimide(DCC)method-weredeveloped.The latter was used successfully to synthesize chelating agents with several catechol units.These compounds are more effective than compounds with only one catechol unit to detoxicate micewhich were under acute UO2(NO3)2 intoxication(LD95～100). |
| 关 键 词： | 铀促排药物 N-羧甲基-N-胺甲酰甲基-2 3-二羟基-4-甲氧羰基苄胺 N N′ N″…多-[N-羧甲基-N-(2 3-二羟基-4-甲氧羰基苄基) |
| 收稿时间： | 1994-01-20 |
STUDIES ON URANIUM MOBILIZATION AGENTS.VIII:NEW METHOD SYNTHSIS OF CHELATING AGENTS WITH CATECHOL RESIDUE |
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| ZH Qin and YY Xie.STUDIES ON URANIUM MOBILIZATION AGENTS.VIII:NEW METHOD SYNTHSIS OF CHELATING AGENTS WITH CATECHOL RESIDUE[J].Acta Pharmaceutica Sinica,1994,29(12):929-933. | |
| Authors: | ZH Qin and YY Xie |
| Abstract: | In further study on the synthesis of chelating agents with catechol residue,twoconvenient procedures-ethyl chloroformate method and dicyclohexylcarbodiimide(DCC)method-weredeveloped.The latter was used successfully to synthesize chelating agents with several catechol units.These compounds are more effective than compounds with only one catechol unit to detoxicate micewhich were under acute UO2(NO3)2 intoxication(LD95～100). |
| Keywords: | N-carboxymethyl-N-(substituted carhamoylmethl)-2 3-dihydroxy-4-carbomethoxybenzylamine N N′ N″ …-poly-(N-carboxymethyl-N-(2 3-dihy-droxy-4-carbomethoxy benzyl)-glycyl)-polyethylene polyamines Uranium mobilization agents |
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