Cytogenetic findings in nodular paragranuloma (Hodgkin's disease with lymphocytic predominance; nodular) and in progressively transformed germinal centers |
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| Authors: | M L Hansmann E G?dde-Salz P K Hui H K Müller-Hermelink K Lennert |
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| Affiliation: | 1. From the Pathologisches Institut der Christian-Albrechts-Universität Kiel, Würzburg, West Germany;2. The Institute für Humangenetik der Christian-Albrechts-Universität Kiel, Würzburg, West Germany;3. the Pathologisches Institut der Universität Würzburg, Würzburg, West Germany;1. Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands;2. Department of Registration, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands;3. Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands;4. Dutch Nationwide Pathology Databank (Palga), Houten, the Netherlands;5. Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands;1. Division of Oncology-Haematology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland;2. Department of Oncology, University Children''s Hospital Zurich, Zurich, Switzerland;3. Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland;4. Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, ON, Canada;5. Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK;6. Department of Neurosurgery, Great Ormond Street Hospital, London, UK;7. Department of Radiology, Alder Hey Children''s NHS Foundation Trust, Liverpool, UK;8. Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK;9. Genetics & Genomic Medicine Research & Teaching Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom;10. Department of Neuro-oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands;11. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands;12. Research Unit Pediatric Oncology, Department Oncology, KU Leuven, Belgium and Pediatric Hemato-Oncology, UZ Leuven, Belgium;13. Neuroradiology Unit, A.O.U. Città della Salute e della Scienza, Turin, Italy;14. Pediatric Onco-Hematology and Cell Transplant Unit, Azienda Ospedaliera di Padova, Italy;15. Hopp Children''s Cancer Center (KiTZ), Heidelberg, Germany;p. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany;q. Department of Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany;r. Department of Ophthalmology, University Medical Center, Utrecht, the Netherlands;s. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany;t. Pediatric Neurosurgery, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany;u. Department of Pediatric Endocrinology, Wilhelmina Children''s Hospital, UMC Utrecht, Utrecht, Netherlands;v. Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands;w. University of Liverpool, UK;x. Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany |
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| Abstract: | Cytogenetic studies were performed in a case of progressively transformed germinal centers (PTGC), and in a case of nodular paragranuloma (NP; Hodgkin's disease with lymphocytic predominance, nodular type). No cytogenetic abnormalities were detected in PTGC. Chromosomal aberrations (hyperdiploidy, 6q-, +21, and several unidentified markers) were found in NP. The results support the proposal that PTGC are reactive in nature and NP is a neoplasm. Chromosomal analysis could provide practical diagnostic aids in the differential diagnosis of PTGC and NP. |
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