一氧化氮等炎性介质与急性坏死性胰腺炎的关系

探讨一氧化氮(NO)等相关炎性介质在急性坏死性胰腺炎(ANP)中的作用。方法:采用3.5％牛磺胆酸逆行胰胆管注射建立鼠的ANP模型,观察NO、内毒素、白细胞介素(IL)-1、IL-6和肿瘤坏死因子(TNFα)的变化,同时观察重组IL-2对ANP的治疗作用。结果:研究结果表明NO参与ANP的病变,与IL_1、I-L6、TNFα和内毒素的释放相平行,又与多器官损伤的严重程度呈正相关。研究结果还发现,重组IL-2的治疗能控制NO、IL_6、IL_1、TNFα和内毒素的过度释放,减轻了ANP的多器官损伤。结论:本研究提示NO在ANP的病损中起重要作用,而且IL_2对ANP有潜在的治疗价值。

Role of Nitric Oxide and Other Inflammatory Mediators in Acute Necrotizing Pancreatitis.

Aims:To study the role of nitric oxide(NO) in rat acute necrotizing pancreatitis(ANP). Methods: The role of NO and its relative factors(endotoxin,IL-l,IL-6,TNF**) were studied in ANP models created by injection of 3.5% sodium taurocholate 2.0ml/kg into pancreatic duct, and the affection of recombinant IL-2 treatment was observed in this experiment. Results: The results indicate that NO take part in ANP aggravation in associated with an increase in serum IL-1,IL-6,TNF**, endotoxin followed by elevation of NO and those mediators are positively correlated with severity of multiple organs damage. The results also suggest IL-2 can inhibit NO.IL-1,IL-6,TNF** and endotoxin overexperession and reduce the incidence of multiple organ damage in ANP. Conclusions: It is suggested that NO plays a major role in participating the pathogenesis of ANP, and IL-2 treatment may play a potential role on ANP.