金盏花流浸膏对大鼠急性放射性皮肤损伤的影响

目的观察金盏花流浸膏对大鼠急性放射性皮肤损伤的作用。方法将36只Wistar雄性大鼠随机分为金盏花组、三乙醇胺组、对照组,每组12只。采用直线加速器6MeV电子线照射,总照射剂量为5 000 cGy/20F,造成大白鼠臀部放射性皮肤损伤,每日于损伤部位涂药2次,评价损伤程度进行比较。结果金盏花组和三乙醇胺组射野内皮肤不良反应均明显低于对照组(P均<0.05),治疗早期三乙醇胺组皮肤放疗不良反应小于金盏花组,最终评价2组间无显著性差异(P>0.05)。结论金盏花流浸膏可明显减轻大鼠的急性放射性皮肤损伤,并促进其早期愈合。

Effects of fluid extracts of Calendula on acute radiation dermatitis in rats

Objective It is to observe the effects of fluid extracts of Calendula on acute radiation dermatitis in rats.Methods Thirty six male Wistar rats were randomly divided into three groups:Calendula group,trolamine group and control group,with 12 rats in each group.An electron beam with 6 MeV energy produced by a linear accelerator was used.The total irradiate dose was 5 000 cGy/20F.This caused acute radiation skin lesions to the gluteal area of rats.Calendula,trolamine were applied topically to the irradiated area twice a day after radiation.Acute skin reactions were evaluated and compared.Results The skin reactions in the Calendula and trolamine groups tended to be less marked than those in the control group(P<0.05).the Calendula group exhibited greater skin reaction than the trolamine group in early treatment stage,but they did not differ significantly at the end of the study(P>0.05).Conclusion Fluid extracts of Calendula can effectively reduce the acute radiation dermatitis damage and promote early healing.