Effect of polychlorinated biphenyls and polychlorinated quaterphenyls in Cynomolgus monkey (Macaca fascicularis) |
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Authors: | S Hori H Obana T Kashimoto T Otake H Nishimura N Ikegami N Kunita H Uda |
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Affiliation: | 1. Osaka Prefectural Institute of Public Health, 1-3-39, Nakamichi, Higashinari-ku, Osaka, Japan;2. Second Department of Pathology, Faculty of Medicine, Osaka University 4-3-57, Nakanoshima, Kita-ku, Osaka, Japan |
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Abstract: | Female Cynomolgus monkeys (Macaca fascicularis) with P-KC-400, Y-PCB, PY-PCB or polychlorinated quaterphenyls (PCQ) received a daily dose of 5 mg for 20 weeks, and some monkeys received a daily dose of 10 mg of Y-PCB or 0.5 mg of PCQ. The chemical compositions of the polychlorobiphenyls (PCB) used for the oral administration were as follows: P-KC-400, PCB from which polychlorodibenzofurans (PCDF) have been removed from Kanecklor 400, largely contains tri- and tetrachlorobiphenyls and no PCDF. Whereas, Y-PCB and PY-PCB, PCB with constituents similar to PCB ingested by yusho patients, largely contain penta- and hexachlorobiphenyls, in addition, PCDF of 400 ppm was present only in Y-PCB, but not in PY-PCB. There were immunosuppression, enlargement and histopathological changes of the liver (such as interstitial inflammation, and proliferation of epithelial cells of biliary duct, etc.) in the groups fed P-KC-400 and PY-PCB (free of PCDF). In the group fed Y-PCB (with PCDF), there were more apparent decreases in body weight, immunosuppression, fatty liver and histopathological changes than in the groups P-KC-400 and PY-PCB. In addition, there were hair loss, acneform eruptions, edema of the eyelid, congestion and abscess of the Meibomian gland, and cornifications of the skin, characteristic dermatological findings of yusho disease. |
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Keywords: | PCB polychlorinated biphenyls PCDF polychlorodibenzofurans PCQ polychlorinated quaterphenyls RER rough endoplasmic reticulum SER smooth endoplasmic reticulum |
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