| 盐酸头孢吡肟合成路线图解 |
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| 引用本文： | 王志贤,张海波,陈言德.盐酸头孢吡肟合成路线图解[J].中国医药导报,2010,7(2):17-18. |
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| 作者姓名： | 王志贤 张海波 陈言德 |
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| 作者单位： | 扬子江药业集团有限公司泰州新药研究院,江苏泰州,225321 |
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| 摘 要： | 本文综述了第四代注射用头孢菌素盐酸头孢吡肟的合成路线，主要是以3-氯代甲基头孢菌素或7-氨基-3-乙酰甲氧基-头孢-3-烯-4-羧酸（7-ACA）为起始原料有2条合成路线，两种方法各有优势，在生产中可根据实际情况来选择适合的路线。
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| 关 键 词： | 盐酸头孢吡肟 合成路线 图解 |
Graphical synthetic routes of cefepime hydrochloride |
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| WANG Zhixian,ZHANG Haibo,CHEN Yande.Graphical synthetic routes of cefepime hydrochloride[J].China Medical Herald,2010,7(2):17-18. |
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| Authors: | WANG Zhixian ZHANG Haibo CHEN Yande |
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| Institution: | (Taizhou New Medicine Research Institution, Yangtze River Pharmaceutical Group, Taizhou 225321, China) |
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| Abstract: | Graphical synthetic mutes of the fourth generation injectable cephalosporin cefepime hydrochloride are re- viewed in this article, mainly based on 3-chlom-methyl cephalosporins, or 7-amino-3-acetyl-methoxy-cephalosporin-3- en-4-carboxylic acid （7-ACA） as the starting material with two synthetic routes, both methods have advantages in the production of the actual situation can select the appropriate line. |
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| Keywords: | Cefepime hydrochloride Synthetic routes Graphic |
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