|
|||||
|
|
Proton pump inhibitors prescribing following the introduction of generic drugs |
|
| Authors: | Cammarota Simona Bruzzese Dario Sarnelli Giovanni Citarella Anna Menditto Enrica Riegler Salvatore Savino Ivana G Vozzella Letizia Piccinocchi Gaetano Napoli Luigi Arpino Giovanni Cuomo Rosario |
| Affiliation: | CIRFF - Center of Pharmacoeconomics and Drug Utilization, Faculty of Pharmacy, University of Naples 'Federico II' Department of Preventive Medical Sciences, Federico II University Hospital School of Medicine Department of Clinical and Experimental Medicine, Gastroenterology Unit, Federico II University Hospital School of Medicine Italian College of General Practitioners, Naples, Italy. |
| Abstract: | Eur J Clin Invest 2012; 42 (10): 1068-1078 ABSTRACT: Background In many countries, the introduction of generic proton pump inhibitors (PPIs) onto the pharmaceutical market increased the phenomenon of therapeutic substitution in acid-related disorders (ARDs). Aim To investigate the treatment of ARDs in an Italian primary care setting from 2005 to 2008 by verifying: (i) dynamics of PPI prescribing; (ii) predictors of PPI switching; and (iii) healthcare resource consumption costs. Methods This was a retrospective cohort study of 102 general practitioners (GPs) who managed an average of 150?000 inhabitants in Naples. Multilevel logistic regression was used to assess the potential predictors of both PPI switching and termination. Primary care costs were expressed as the cost of ARD management per PPI user year. Results The percentage of PPI users with ARD increased from 5·5% (2005) to 7·0% (2008) (P? |
| Keywords: | Acid‐related disorders primary care proton pump inhibitors |
| 本文献已被 PubMed 等数据库收录！ | |