Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up |
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Authors: | Zhou Letian Li Ying Liu Fuyou Peng Youming Liu Yinghong Li Jun |
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Institution: | Division of Nephrology, Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, Hunan, PR China. |
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Abstract: | Acute tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease usually having a good prognosis. But the recurrence of uveitis and the chronic progression of kidney injury are still main problems. We report a 15-year-old girl with TINU who showed proteinuria, pathological renal change, multiple organ dysfunction, and immune disorders. After 2 months of 1 mg/kg/day corticosteroid therapy, 24-h urine protein, liver function tests, and creatine kinase returned to normal level. In spite of this, steroid was tapered off slowly and small dose of steroid maintenance therapy lasted for 1 year. Her kidney and ocular symptoms did not recur during 5 years of follow-up. We suggest low-dose steroid maintenance therapy to decrease the recurrence of the TINU syndrome. |
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