幽门螺杆菌与胃癌nm23,c—erbB2基因表达及术后再发癌的关系

目的：探讨胃癌组织幽门螺杆菌（Ｈｐ） 感染和ｎｍ２３ 、ｃｅｒＢ２ 表达及胃癌根治术后再发癌之间的关系。方法：用ＷａｒｒｔｈｉｎＳｔａｒｒｙ 方法检测胃组织幽门螺杆菌感染，采用免疫组化ＳＰ法检测６４ 例胃癌组织ｎｍ２３、ｃｅｒＢ２ 表达，并结合内镜及随访资料进行分析。结果：胃癌Ｈｐ 感染率、ｎｍ２３ 低表达率及ｃｅｒＢ２ 阳性率，在淋巴结转移组及术后３ 年内有再发癌组明显增高。而且ｎｍ２３ 低表达与肿瘤浸润程度有关，浸及浆膜及周围脏器组ｎｍ２３ 低表达率为７８－６％ ，浸及粘及粘膜下者为４０－０％ （Ｐ＜ ０ ．０５） 。Ｈｐ 感染者ｃｅｒＢ２ 阳性率、ｎｍ２３ 低表达率明显高于Ｈｐ 阴性组。结论：Ｈｐ 在胃癌发生、发展过程中起着重要作用。它可能通过影响癌基因蛋白的表在起促癌作用。胃癌ｎｍ２３ 低表达和ｃｅｒＢ２ 阳性表达者具有较强的浸润转移能力，且术后易发生再发癌，二者的表达变化对判断胃癌术后再发癌的发生及预后有重要意义。

Helicobacter pylori infection and nm23, c-erbB 2 proto-oncogene protein expression in human gastric cancer tissue.

Objective To explore the relationship between helicobacer helicobacer pylori(Hp) and nm23 and c-erbB 2 proto-oncogene protein expression in gastric cancer and recurrent cancer.Methods:Hp was detrected by Warrthin-Starry method,the expression of nm23 and c-erbB 2 in64 cases of gastric cancer were examined by S-P immunohistochemical method, and the rrslts were analyzed in combination with gastroscopy and follow-up materials. Results:nm23 low-expression rate and cerbB 2 positive rate in Hp infecition carcinoma tissue were much higher than Hp negative ones. nm23 low-expression rate and c-erbB 2 positive rate and Hp infection rate of the groups with lymph metastasis or recurrent cancer were obviously higher than the groups without metastasis or recurence.And nm23 low-expression was remarkably related to the depth of cancer invasion. nm23 low-expression rate was 78.6% in the carcinoma invading serosa and peripheral organs, and 40.0$ invading mucosa and submucosa(P<0.05).Conclusions:Hp play an important role in carciongenesis of stomach. Hp can promote carcinogenesis by affecting oncogene protein expression. nm23 lowexprssion and c-erbB 2 positive expression may play an important role in lymph node metastasis and invasion of gastric cancer,and recurrent cancer after operation. The detection of recurrent cancer and prognosis.