Auditory P300 response in the assessment of Alzheimer's disease in Down's syndrome: a 2-year follow-up study |
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| Authors: | W. J. MUIR I. SQUIRE D. H. R. BLACKWOOD M. D. SPEIGHT D. M. ST CLAIR C. OLIVER P. DICKENS |
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| Affiliation: | University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh, Scotland;Bethlem and Maudsley Hospital, London, England;Royal Scottish National Hospital, Larbert, Stirlingshire, Scotland |
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| Abstract: | ABSTRACT. Sixty-five subjects with Down's syndrome were followed up and retested 2 years after the initial recording ni auditory P300 (P3) event-related potential described in a companion paper (Blackwood et al. , 1988). The number of subjects showing clinical evidence for Alzheimer's type dementia had increased by a further 14%. In subjects showing clinical deterioration over a period of 2 years, 78% (7/9) had an increase in P3 latency which was three standard deviations or greater than the group mean. None of the 20 fragile-X group retested showed significant change after 2 years. The results suggest that P3 change may be a sensitive index of the onset of Alzheimer's type dementia in Down's syndrome. |
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