| 干扰素诱导HBV基因突变后再次抗病毒疗效 |
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| 引用本文： | 刘盼,余祖江.干扰素诱导HBV基因突变后再次抗病毒疗效[J].河南医学研究,2014,23(2):25-27. |
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| 作者姓名： | 刘盼 余祖江 |
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| 作者单位： | 刘盼 (郑州大学第一附属医院感染科 河南郑州450052)； 余祖江 (郑州大学第一附属医院感染科 河南郑州450052)； |
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| 摘 要： | 目的:探讨慢性乙型肝炎(CHB)患者应用普通干扰素(IFN)诱导HBV基因突变后的再次抗病毒疗效。方法:选择44例持续接受IFN治疗无效者检测出HBV-C区C基因启动子(CP)/前C/C基因]突变的CHB患者,根据其再次抗病毒治疗药物的选择,分为聚乙二醇干扰素(PEG-IFN)组(A组)和拉米夫定组(B组),分析治疗6个月后HBV-DNA及ALT的变化。结果:抗病毒治疗6个月后,A组的ALT复常率及HBV-DNA阴转率分别为31.25%和37.50%,B组分别为75.00%和82.14%,两组差异有统计学意义(P<0.05)。结论:IFN诱导HBV-C区基因突变后,拉米夫定较PEG-IFN抗病毒疗效好。
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| 关 键 词： | 慢性乙型肝炎 干扰素诱导突变 抗病毒治疗 |
The second antiviral efficacy after interferon-induced HBV gene mutation |
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| LIU Pan,YU Zujiang.The second antiviral efficacy after interferon-induced HBV gene mutation[J].Henan Medical Research,2014,23(2):25-27. |
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| Authors: | LIU Pan YU Zujiang |
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| Institution: | ( Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) |
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| Abstract: | Objective ： To explore the efficacy of the second antiviral treatment after common inter- feron-induced HBV gene mutation. Methods： 44 patients with HBV-C region core promoter （CP） and the precore/core gene] mutations after common interferon treatment were collected. Then they were divided into group A （treated by pegylated interferon） and group B （treated by lamivudine） according to different anti-virus drugs. The changes of the levels of HBV-DNA and ALT in two groups were analyzed after 6 months＇ treatment. Results： The rates of ALT normaliza- tion and HBV-DNA negative-converting were 75. 00% , 82. 14% in group A and 31. 25% , 37.50% in group B, the differences were of statistical significance antiviral efficacy of Lamivudine is better than pegylated interferon duced HBV-C area gene mutation. P 〈 0.05 ）. Conclusion ： The n patients with interferon-in- |
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| Keywords: | chronic hepatitis B interferon-induced mutation antiviral treatment |
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