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The actions of adenosine and some analogues on evoked and potassium stimulated release at skeletal and autonomic neuromuscular junctions
Authors:P. J. Buckle  I. Spence
Affiliation:(1) Roche Research Institute of marine Pharmacology, PO Box 299, 2099 Dee Why, NSW, Australia;(2) Department of Pharmacology, University of Sydney, 2006, NSW, Australia
Abstract:Summary The actions of the nucleosides adenosine, 1-methyladenosine, 1-methylisoguanosine and 2-chloradenosine on transmitter release at the mammalian neuromuscular junction and the vas deferens have been examined. All the nucleosides depressed the evoked release of acetylcholine at the neuromuscular junction, the order of potency being 2-chloroadenosine > 1-methylisoguanosine > 1-methyladenosine Gt adenosine. This correlated reasonably with the potency of these compounds in depressing spinal reflexes in anaesthetized mice (Buckle and Spence 1981). Neither adenosine (0.5 and 1.0 mmol l–1) or 1-methylisoguanosine (10 and 20 mgrmol l–1) had any effect on the elevation of minature endplate potential frequency caused by 12 mmol l–1 K+ at the neuromuscular junction. In the guinea-pig vas deferens, however, 1-methylisoguanosine and adenosine were approximately equipotent in depressing overflow of radioactively labelled noradrenaline. The actions of the nucleosides have been compared with their effects on adenylate cyclase and their ability to resist uptake and deamination. It is concluded that the relative potencies of the nucleosides are not determined solely by their ability to survive in the extracellular fluid.
Keywords:Nucleosides analogues and derivatives  Neuromuscular junction  Vas deferens
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