急性胰腺炎发病机理的研究进展

目的总结急性胰腺炎发病机理的研究进展。方法分析近年来国内、外有关急性胰腺炎发病机理的文献报道。结果实验数据表明，促炎性细胞因子和趋化因子的合成与释放对于局部损伤和炎性介质的全身播散起着重要作用，同时提示免疫系统，包括淋巴细胞和中性粒细胞的活化，在胰腺炎的发展过程中也起一定作用。另外，胰腺在一次发病之后可以完全恢复，也可以纤维化，星状细胞被认为在胰腺成纤维过程中起着极其重要的作用。结论急性胰腺炎的发病机理非常复杂，在疾病发作后能够决定其严重程度的因子仍然未知。

Progression of Pathogenetic Research of Acute Pancreatitis

Objective To summarize the recent pathogenetic researches on the acute pancreatitis. Methods Relevant references about the pathogenesis of acute pancreatitis, which were published recently domestic and abroad were collected and reviewed. Results Recent experimental data indicated that the synthesis and release of pro-inflammatory cytokines and chemotactic factors were responsible for local injury and systemic dissemination of the inflammatory mediators. Experimental studies also provided evidences implying that the immune system might play a role in the development of pancreatitis, such as the activation of lymphocyte and neutrophil. Additionally, the pancreas may completely recover or become fibrotic after an attack of acute pancreatitis and the presence of pancreatic stellate cell was known as a crucial factor in the fibrogenesis. Conclusion The pathogenesis of acute pancreatitis is very complicated, the factors that determine the ultimate severity of the attack are still unknown.