Hepatotoxicity of ethanol in mice. |
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Authors: | R. D. Goldin S. N. Wickramasinghe |
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Affiliation: | Department of Experimental Pathology, St Mary''s Hospital Medical School, University of London, UK. |
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Abstract: | Mice continuously exposed to ethanol vapour (for up to 19 days) developed fatty change in the liver (from 2 days onwards) and lesions resembling those of alcoholic hepatitis in man (from 5 days onwards). They also showed biochemical evidence of liver cell damage. Sera from ethanol-treated animals contained immunoglobulins that bound to the hepatocytes of ethanol-treated but not of control animals suggesting that exposure to ethanol was followed by an immunological response to a hepatocyte neo-antigen. In addition, such sera were cytotoxic in an in-vitro assay, and on Sephacryl S-300 gel filtration the cytotoxic activity eluted together with albumin molecules. |
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