Survivin及P53在唾液腺腺样囊性癌中表达的研究 |
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引用本文: | 王雪峰,;李善昌,;房殿吉,;宁兆荣,;宁尚波,;闫磊,;姜炳华. Survivin及P53在唾液腺腺样囊性癌中表达的研究[J]. 口腔医学研究, 2014, 0(7): 635-637 |
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作者姓名: | 王雪峰, 李善昌, 房殿吉, 宁兆荣, 宁尚波, 闫磊, 姜炳华 |
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作者单位: | [1]佳木斯大学口腔医院颌面外科,黑龙江佳木斯154002; [2]复旦大学附属上海市第五人民医院口腔科,黑龙江佳木斯154002; |
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基金项目: | 国家自然科学基金(编号:81170935);黑龙江省教育厅科学技术研究项目(编号:1252155) |
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摘 要: | 目的:研究Survivin及P53在唾液腺腺样囊性癌(Salivary adenoid cystic carcinoma,SACC)中的表达,探讨其与临床病理因素的关系及两者的相关性。方法:采用SP免疫组织化学染色方法检测36例SACC及10例癌旁正常涎腺组织标本中Survivin及P53的表达,采用SPSS13.0软件行统计分析。结果:SACC组织中Survivin及P53阳性表达率分别为66.67%、69.44%。两者的表达与临床分期密切相关;P53还与淋巴转移、肿瘤病理类型相关,癌旁正常腮腺组织未见两者表达。结论:Survivin及P53可能与SACC的发生、发展有关。
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关 键 词: | Survivin 唾液腺腺样囊性癌P53 免疫组织化学 |
Expression of Survivin and P53 in Salivary Adenoid Cystic Carcinoma |
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Affiliation: | WANG Xue-feng, LI Shan-chang, FANG Oian-ji, et al.(Department of Oral and Maxillofacial Surgery, Jiamusi University, Jiamusi 154002) |
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Abstract: | Objective:To evaluate the clinical significance of Survivin and P53expression in salivary adenoid cystic carcinoma(SACC)and its relationship.Methods:Immunohistochemical staining(SP)was used to quantify Survivin and P53expression in specimens from 36patients with SACC and normal parotid gland tissues nearby from 10patients as control.SPSS13.0statistical software was used.Results:The expression rates of Survivin and P53in the36cases of SACC were 66.67%and 69.44%respectively.The positive rate of Survivin and P53strongly associated clinicopathologic stage.P53associated with lymphatic metastasis and pathology category.Survivin and P53were not expressed at adjacent normal parotid gland tissues.Conclusion:Survivin and P53may participate in the onset and development of SACC.Quantification of Survivin and P53in SACC may provide a valuable marker for prognosis of patients with SACC. |
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Keywords: | Survivin Salivary adenoid cystic carcinoma P53 Immunohistochemistry |
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