乳果糖治疗肝性脑病疗效观察

目的观察乳果糖在重症肝炎并肝性脑病的治疗效果;方法通过对我科2008年至2010年收治的62例重肝并肝性脑病患者按常规治疗及加用乳果糖口服、灌肠治疗的疗效观察及采用酶法测定62例重型肝炎患者的血氨含量比较。结果乳果糖治疗2周后能显著降低重肝患者血氨水平。乳果糖口服及灌肠使用对治疗重肝、肝性脑病、降低血氨较常规治疗更有意义。结论血氨增高在肝性脑病的发病机制中起着十分重要的作用,血氨监测对重肝及肝硬化的诊断、治疗及预后判断具有重要的意义。而乳果糖治疗2周后能显著降低重肝患者血氨含量。

The Rapeutic Effects of Lactulose on Hepatic Encephalopathy

Objective To investigate the therapeutic effects of lactulose in fatal hepatitis patients with hepatic encephalopathy. Methods Sixty two fatal hepatitis patients with hepatic encephalopathy during year 2008-2010 were investigated. The therapeutic outcomes were compared between routine treatments and routine plus lactulose oral administration or enteroclysm. Blood ammonia levels were detected by enzyme assay in all these 62 patients. Results Lactulose treatment for two weeks could significantly reduce the blood ammonia levels in fatal hepatitis patients. Lactulose oral administration or enteroclysm plus routine treatments showed better therapeutic effects than routine treatments in fatal hepatitis patients with hepatic encephalopathy. Conclusion Blood ammonia increase played an important role in the pathogenesis of hepatic encephalopathy. Its levels showed important role in the diagnosis, treatment and prognosis of fatal hepatitis and liver cirrhosis. Lactulose treatment for two weeks could significantly reduce the blood ammonia levels in fatal hepatitis patients.