Hippocampal stimulation and memory: effects of stimulation parameters and reinforcement magnitude |
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Authors: | B S Kapp J D Kaufman D A Repole |
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Affiliation: | Department of Psychology, University of Vermont, Burlington, Vermont 05401 USA |
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Abstract: | The present study investigated the extent to which post-conditioning stimulation-induced hippocampal seizure activity is a necessary condition for the production of retrograde amnesia in rats. Groups of animals received dorsal hippocampal stimulation at several different current intensities immediately following one-trial passive avoidance conditioning. The results suggest that current intensities far in excess of those which produce hippocampal seizure activity are a necessary condition for the production of retrograde amnesia. Reinforcement magnitude is not a significant variable at hippocampal seizure threshold current intensities. Current intensities insufficient for the production of retrograde amnesia, but sufficient for the production of dorsal hippocampal seizure activity, produced a spread of seizure activity into the ventral hippocampal formation. The results suggest that caution be exercised in attributing a role to the hippocampus in memory consolidation processes in the rat. |
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Keywords: | Memory consolidation Passive avoidance conditioning Hippocampal stimulation Hippocampal seizure activity |
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