| 免疫吸附清除循环TNF对组织中TNF和IL-8水平的影响 |
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| 引用本文： | 唐斌,张训,侯凡凡. 免疫吸附清除循环TNF对组织中TNF和IL-8水平的影响[J]. 南方医科大学学报, 1998, 0(1) |
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| 作者姓名： | 唐斌 张训 侯凡凡 |
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| 作者单位： | 第一军医大学南方医院全军肾病中心!广州510515 |
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| 基金项目： | 国家自然科学基金!39370336 |
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| 摘 要： | 用新西兰白兔建立内毒素休克模型，以亲和免疫吸附清除循环中TNF，观察对动物心、肝、肺、肾组织中TNF和IL－8水平的影响。结果表明，能有效清除循环中TNF，并使组织中TNF和IL－8水平明显降低。
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| 关 键 词： | 免疫吸附 组织 肿瘤坏死因子 白细胞介素－8 |
The effect of removing circulatory TNF by immunoadsorption on tissue levels of TNF and IL-8 in endotoxin skock |
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| Tang Bin,Zhang Xun,Hou Fanfan. The effect of removing circulatory TNF by immunoadsorption on tissue levels of TNF and IL-8 in endotoxin skock[J]. Journal of Southern Medical University, 1998, 0(1) |
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| Authors: | Tang Bin Zhang Xun Hou Fanfan |
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| Abstract: | New Zealand white rabbits injected with lethal dose of endotoxin were undergone hemoperfusion through immunoadsorbent,and the plasma levels of TNF were sequentially detected. After 2 h of hemoperfusion through immunoadsorbent,not only plasma TNF levels,but also TNF and IL-8 levels in tissues were significantly lower than those in endotoxin group (P<0.01). The study shows that TNF have regulation effect on IL-8 levels;therefore, removing TNF may amplify the protective effects on endotoxin shock. |
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| Keywords: | immunoadsorption tissue tumor necrosis factor interleukin-8 |
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