| 几种哺乳动物骨形态发生蛋白的同源性分析 |
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| 引用本文： | 刘英芹,张淑红,朱金玲,殷博,朱开梅,孙广臣.几种哺乳动物骨形态发生蛋白的同源性分析[J].海南医学院学报,2011,17(4):441-444. |
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| 作者姓名： | 刘英芹 张淑红 朱金玲 殷博 朱开梅 孙广臣 |
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| 作者单位： | 1. 桂林医学院,广西桂林,541004
2. 佳木斯大学,黑龙江佳木斯,1540017 |
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| 基金项目： | 广西教育厅科研资助项目，黑龙汀中医药管理局科学技术研究项目，佳木斯大学科研项目 |
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| 摘 要： | 目的:分析人类、黑猩猩及小鼠的BMPs同源性,为缩小动物实验与人体实验间差距提供依据。方法:从美国国家生物信息中心(NCBI,National Center for Biotechnology Information)的数据库中检索人类、黑猩猩、牛及小鼠的BMP的核酸及氨基酸序列,分别用软件BLAST、ClustalW进行基因及蛋白质分析,由TreeView绘制系统树结构图。结果:与人类BMPs核酸序列同源性,黑猩猩>牛>小鼠;人类的BMPs家族分为7个组,牛的分组情况与人类的近似,小鼠的分组与人类的差别较大。结论:和小鼠相比,以牛为实验动物研究BMPs的实验结果更接近人体实验的数据。
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| 关 键 词： | BMP 同源性 牛 小鼠 |
Analysis on homology of BMPs from human,orangutan,cattle and rat |
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| LIU Ying-qin,ZHANG Shu-hong,ZHU Jin-ling,YIN Bo,ZHU Kai-mei,SUN Guang-chen.Analysis on homology of BMPs from human,orangutan,cattle and rat[J].Journal of Hainan Medical College,2011,17(4):441-444. |
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| Authors: | LIU Ying-qin ZHANG Shu-hong ZHU Jin-ling YIN Bo ZHU Kai-mei SUN Guang-chen |
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| Institution: | LIU Ying-qin1,ZHANG Shu-hong2,ZHU Jin-ling2,YIN Bo2,ZHU Kai-mei1,SUN Guang-chen1(1.Guilin Medical College,Guilin Guangxi 541004,2.Jiamusi University,Jiamusi Heilongjiang 1540017,China) |
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| Abstract: | Objective: To analyze homology of BMPs from human,orangutan,bovine and rat in order to find substitute animals for human experiments.Methods: Nucleic acid and amino acid sequences of BMPs were obatained from the National Center for Biotechnology Information,then analyzed with BLAST and ClustalW software.Results: The nucleotide homology with the human sequence was: orangutan>cattle >rat;human BMPs family were divided into 7 groups,similar categories were found in cattle,while categories in rat were greatly v... |
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| Keywords: | BMP |
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